https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19686 Wed 27 Jul 2022 13:51:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45243 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45239 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44995 Wed 26 Oct 2022 09:22:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55180 Wed 24 Apr 2024 09:33:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40957 Wed 20 Jul 2022 16:04:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40187 Wed 20 Jul 2022 14:17:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37230 Wed 19 Jan 2022 15:15:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38204 Wed 18 Aug 2021 09:53:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37096 Wed 17 Nov 2021 16:30:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36829 Wed 17 Nov 2021 16:30:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46370 Wed 16 Nov 2022 08:45:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48377 Wed 15 Mar 2023 13:54:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33086 Wed 15 Dec 2021 16:08:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33590 Wed 15 Dec 2021 16:08:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47141 Wed 14 Dec 2022 15:27:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47146 Wed 14 Dec 2022 15:27:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47119 Wed 14 Dec 2022 12:25:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32515 M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.]]> Wed 13 Jun 2018 11:02:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32518 Wed 13 Jun 2018 11:02:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25895 0.05). Chronic treatment of combination of genistein (10 mg/kg) and amitriptyline (5 mg/kg and 10 mg/kg) significantly reduced the immobility time as compared to control group (p<0.001) and was comparable to amitriptyline alone (10 mg/kg). However, no changes in anti-immobility activity in combination of subeffective doses of genistein (5 mg/kg) and amitriptyline (5 mg/kg) were observed. Genistein at its standard dose (10 mg/kg) rendered synergistic effects in combination with subeffective dose of amitriptyline (5 mg/kg) and additive effects in combination with therapeutic dose of amitriptyline (10 mg/kg).]]> Wed 11 Apr 2018 17:08:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29589 Wed 11 Apr 2018 14:43:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30351 1 or CGRP₂ receptor in which it demonstrates similar high-affinity binding for salmon calcitonin, CGRP, and amylin, a possession which is not shared by any extra CGRP receptors. Binding of CGRP to its receptor increases activated cAMP-dependent pkA and PI3 kinase, resulting in N-terminal fragments that are shown to exert complex inhibitory as well facilitator actions on nAChRs. Fragments such as CGRP1-4, CGRP1-5, and CGRP1-6 rapidly as well as reversibly improve agonist sensitivity of nAChRs without straight stimulating those receptors and produce the Ca²⁺-induced intracellular Ca²⁺ mobilization. Renin–angiotensin–aldosterone system (RAAS)-activated angiotensin-type (AT4) receptor is also beneficial in AD. It has been suggested that exogenous administration of CGRP inhibits infiltration of macrophages and expression of various inflammatory mediators such as NFkB, IL-1b, TNF-α, iNOS, matrix metalloproteinase (MMP)-9, and cell adhesion molecules like intercellular adhesion molecule (ICAM)-1 which attenuates consequence of inflammation in AD. Donepezil, a ChEI, inhibits acetylcholinesterase and produces angiogenesis and neurogenesis, in the dentate gyrus of the hippocampus of WT mice after donepezil administration. However, none of the results discovered in CGRP-knockout mice and WT mice exposed to practical denervation. Therefore, selective agonists of CGRP receptors may become the potential candidates for treatment of AD]]> Wed 10 Nov 2021 15:13:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53698 Wed 10 Jan 2024 10:49:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44524 Wed 09 Nov 2022 10:21:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36822 Cissus arnotiana and evaluated their antibacterial activity against gram negative and gram positive bacteria. The morphology and characterization of the synthesized CuNPs were studied and done using UV-Visible spectroscopy at a wavelength range of 350–380 nm. XRD studies were performed for analyzing the crystalline nature; SEM and TEM for evaluating the spherical shape within the size range of 60–90 nm and AFM was performed to check the surface roughness. The biosynthesized CuNPs showed better antibacterial activity against the gram-negative bacteria, E. coli with an inhibition zone of 22.20 ± 0.16 mm at 75 μg/ml. The antioxidant property observed was comparatively equal with the standard antioxidant agent ascorbic acid at a maximum concentration of 40 μg/ ml. This is the first study reported on C. arnotiana mediated biosynthesis of copper nanoparticles, where we believe that the findings can pave way for a new direction in the field of nanotechnology and nanomedicine where there is a significant potential for antibacterial and antioxidant activities. We predict that, these could lead to an exponential increase in the field of biomedical applications, with the utilization of green synthesized CuNPs, due to its remarkable properties. The highest antibacterial property was observed with gram-negative strains mainly, E. coli, due to its thin peptidoglycan layer and electrostatic interactions between the bacterial cell wall and CuNPs surfaces. Hence, CuNPs can be potent therapeutic agents in several biomedical applications, which are yet to be explored in the near future.]]> Wed 08 Jul 2020 13:55:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43998 Wed 05 Oct 2022 15:10:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47835 Wed 01 Feb 2023 14:10:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54046 Tue 30 Jan 2024 13:50:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54474 Tue 27 Feb 2024 14:35:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44965 Tue 25 Oct 2022 13:46:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47625 Tue 24 Jan 2023 14:02:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49602 Tue 23 May 2023 15:26:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53314 Tue 21 Nov 2023 12:37:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53287 Tue 21 Nov 2023 10:23:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48577 Tue 21 Mar 2023 17:30:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42000 Tue 16 Aug 2022 16:44:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41999 Tue 16 Aug 2022 16:44:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41998 Tue 16 Aug 2022 16:37:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41952 Tue 16 Aug 2022 14:38:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46354 Tue 15 Nov 2022 14:40:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46318 Tue 15 Nov 2022 11:45:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46280 Tue 15 Nov 2022 08:30:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44237 Artemisia vulgaris is a traditional Chinese herb believed to have a wide range of healing properties; it is traditionally used to treat numerous health ailments. The plant is commonly called mugwort or riverside wormwood. The plant is edible, and in addition to its medicinal properties, it is also used as a culinary herb in Asian cooking in the form of a vegetable or in soup. The plant has garnered the attention of researchers in the past few decades, and several research studies have investigated its biological effects, including antioxidant, anti-inflammatory, anticancer, hypolipidemic, and antimicrobial properties. In this review, various studies on these biological effects are discussed along with the tests conducted, compounds involved, and proposed mechanisms of action. This review will be of interest to the researchers working in the field of herbal medicine, pharmacology, medical sciences, and immunology.]]> Tue 11 Oct 2022 12:13:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39066 in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-a in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.]]> Tue 03 May 2022 12:13:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36990 Thu 28 Oct 2021 12:36:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42198 Thu 25 Aug 2022 11:34:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53392 Thu 23 Nov 2023 13:37:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53391 Thu 23 Nov 2023 13:37:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53385 Thu 23 Nov 2023 12:55:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53373 Thu 23 Nov 2023 11:03:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33587 Thu 22 Nov 2018 13:41:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33594 Thu 22 Nov 2018 13:41:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33591 Thu 22 Nov 2018 13:41:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33589 Thu 22 Nov 2018 13:41:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33592 Auricularia polytricha is a popular mushroom found all over the world. In this study we considered the effect of an aqueous extract of A. polytricha (AEAP) on restoring sexual performance parameters to normal, evaluated by considering observations of sexual behavior. At 0, 6, 12, 18, and 24 days, the following parameters of sexual performance were identified before and throughout the observations: mount latency, intromission latency, ejaculation latency, mounting frequency, intromission frequency, ejaculation frequency, and postejaculatory interval. Treatment of rats under stress with AEAP showed promising effects on overcoming stress-induced sexual dysfunction, on sexual performance, and on accessory sexual organs and body weight. Mounting latency, intromission latency, ejaculation latency, and postejaculatory interval parameters were significantly decreased by AEAP, whereas mounting frequency, intromission frequency, and ejaculation frequency were significantly increased by AEAP. These properties were identified in sexually dynamic and indolent male rats. We conclude that AEAP has a potent aphrodisiac activity.]]> Thu 22 Nov 2018 13:41:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40998 Thu 21 Jul 2022 10:30:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38949 Thu 17 Mar 2022 08:49:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43359 Thu 15 Sep 2022 15:39:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39877 Thu 14 Jul 2022 13:40:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39904 Thu 14 Jul 2022 11:58:51 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36874 Thu 14 Apr 2022 11:00:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36704 Thu 09 Dec 2021 11:02:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33586 Thu 03 Feb 2022 12:21:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33588 Mycobacterium tuberculosis, Mtb) treatment involves multiple drug regimens for a prolonged period. However, the therapeutic benefit is often limited by poor patient compliance, subsequently leading to treatment failure and development of antibiotic resistance. Notably, oxidative stress is a crucial underlying factor that adversely influences the various treatment regimens in tuberculosis. Little information is available with advanced drug delivery systems that could be effectively utilized, in particular, for targeting the oxidative stress in tuberculosis. Thus, this presents an opportunity to review the utility of various available, controlled-release drug delivery systems (e.g., microspheres, liposomes, niosomes, solid lipid nanoparticles, dendrimers) that could be beneficial in tuberculosis treatments. This will help the biological and formulation scientists to pave a new path in formulating a treatment regimen for multi-drug resistant Mtb.]]> Thu 03 Feb 2022 12:21:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29637 Sat 24 Mar 2018 07:41:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31020 Sat 24 Mar 2018 07:34:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30137 Sat 24 Mar 2018 07:34:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38279 Blepharis is an Afro-Asiatic genus belonging to the family Acanthaceae. It comprises about 126 species that occur in arid and semi-arid habitats. Some species of Blepharis are used in traditional medicines in different countries mainly for their anti-inflammatory, wound healing activities along with treatment of gastrointestinal disorders and bone fractures. Aim of the review: The present review aims to collate and analyze the available data and information on distribution, traditional uses, chemical constituents and pharmacological activities of Blepharis. Methods: Scientific information of genus Blepharis was retrieved from the online bibliographic databases such as MEDLINE/PubMed, SciFinder, Web of Science and Google Scholar and secondary resources including books and proceedings. Results: Seven species of Blepharis were found to be reported frequently as useful in folklore in African and Asian countries. B. maderaspatensis was found to be widely used in Indian traditional medicines whereas the B. ciliaris and B. edulis were common in folklore of Egypt, Jordan, and Arabia. Active phytochemicals of Blepharis are flavonoids from B. ciliaris, alkaloids from B. sindica, phenolic acid derivatives, and phytosterols, and derivatives of hydroxamic acids from B. edulis resulted in possessing diverse biological properties such as anti-microbial, anti-inflammatory, and anti-cancer. Conclusions: Various species of Blepharis were found to be used in traditional medicine systems in African and Asian countries. Few of these species were studied for their bioactive chemical constituents however the activity guided isolation studies are not performed. Similarly, detailed pharmacological studies in animal models to explore their mechanism of action are also not reported. Future studies should focus on these aspects related to the medicinally used species of Blepharis. The detailed and comprehensive comparative analysis presented here gives valuable information of the currently used Blepharis species and pave the way to investigate other useful species of Blepharis pertaining to ethnobotany, phytochemistry and discovery of new drugs.]]> Mon 29 Jan 2024 18:52:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38437 Mon 29 Jan 2024 18:01:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46664 Mon 28 Nov 2022 18:32:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46616 Mon 28 Nov 2022 10:47:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46614 Mon 28 Nov 2022 10:43:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49577 Mon 22 May 2023 10:51:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48492 Mon 20 Mar 2023 12:13:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48491 Punica granatum. Method: Rosmarinic acid was isolated by bioactivity-guided isolation from butanolic fraction of Punica granatum and acute toxicity of rosmarinic acid was carried out. The experiment was conducted at doses of 25 and 50 mg/kg, in Freund's complete adjuvant (FCA)-induced arthritic rats. Various parameters, that is arthritic score, paw volume, thickness of paw, hematological, antioxidant and inflammatory parameters such as glutathione (GSH), superoxide dismutase (SOD), malonaldehyde (MDA) and tumor necrosis factor-a (TNF-a) were also estimated. Results: Rosmarinic acid significantly decreased the arthritic score, paw volume, joint diameter, white blood cell count and erythrocyte sedimentation rate. It also significantly increased body weight, hemoglobin and red blood cells. The significantly decreased levels of TNF-a were observed in treated groups as compared to arthritic control rats (P < 0.001). At the same time antioxidant parameters (like GSH and SOD) were increased significantly while levels of MDA were significantly decreased (P < 0.001). Conclusion: The outcome of the present research concludes that rosmarinic acid showed significant anti-arthritic potential in FCA-induced arthritis in Wistar rats. This study represented the therapeutic role of rosmarinic acid from Punica granatum for the management of arthritis/rheumatoid arthritis/osteoarthritis and related inflammatory complications with negligible side effects which was still far from complete mitigation with available conventional medicines.]]> Mon 20 Mar 2023 11:51:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54715 Mon 18 Mar 2024 15:49:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44588 Mon 17 Oct 2022 13:57:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44177 Mon 10 Oct 2022 10:20:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38563 Mon 09 May 2022 16:16:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49262 Mon 08 May 2023 11:02:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41301 Mon 01 Aug 2022 12:16:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42171 Fri 26 Aug 2022 08:02:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37006 Fri 22 Apr 2022 10:21:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38456 Fri 17 Sep 2021 15:35:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39655 Fri 17 Jun 2022 13:47:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43386 Fri 16 Sep 2022 09:30:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47212 Fri 16 Dec 2022 10:09:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38589 Fri 12 Nov 2021 15:59:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41789 Fri 12 Aug 2022 12:17:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46115 Fri 11 Nov 2022 14:39:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46080 Fri 11 Nov 2022 10:10:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45754  90%), and negative zeta potential (−1.42 ± 0.25% mV) values. ME hydrogel composite with optimum rheological and textural attributes showed better permeation, retention, and skin-compliant characteristics, vis-a-vis marketed formulation (Aziderm™) when evaluated in Wistar rat skin. In vitro antibacterial efficacy in bacterial strains, i.e., Staphylococcus aureus, Propionibacterium acne, and Staphylococcus epidermidis, was evaluated employing agar well plate diffusion and broth dilution assay. ME hydrogel has shown an increase in zone of inhibition by two folds and a decrease in minimum inhibitory concentration (MIC) by eightfold against P. acnes vis-a-vis AzA. Finally, ME hydrogel composite exhibited a better reduction in the papule density (93.75 ± 1.64%) in comparison to Aziderm™ 72.69 ± 4.67%) on acne as developed in rats by inducing testosterone. Thus, the developed AzA-TTO ME hydrogel composite promises an efficacious and comparatively safer drug delivery system for the topical therapy of acne vulgaris.]]> Fri 04 Nov 2022 10:41:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45706 Fri 04 Nov 2022 08:55:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42789 Fri 02 Sep 2022 14:04:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33593 Fri 01 Apr 2022 09:22:45 AEDT ]]>